Use the tab key to navigate the form. It is a useful tool to determine the rate of pump medication infusion to achieve therapeutic dosing.
Pdf Weight Based Argatroban Dosing Nomogram For Treatment Of Heparin Induced Thrombocytopenia
Critically-ill patients with normal hepatic function have become excessively anticoagulated with FDA-approved or lower starting doses of argatroban.
. 25 mcgkgmin IV infusion AND. 26 for low-dose argatroban and 43 for high-dose argatroban26106. A bolus of 350 mcgkg IV over 3-5 minutes via large-bore IV line.
Standard Argatroban Infusion is 250mg in Normal Saline 250mL yielding a concentration of 1 mgmL or 1000 mcgmL. Bleeding rates were lower but not significantly in patients receiving argatroban 10 for heparin vs. Start dose amount not defined titrate slowly.
Hepatic dz or ASTALT 3x ULN. Hepatic dosing anticoagulation Child-Pugh Class A. There are no specific guidelines for dosing in hepatic impairment and therefore argatroban should be avoided in patients with any degree of hepatic impairment.
TIMI grade 3 blood flow at 90 minutes trended towards improvement with argatroban. Argatroban interferes with the INR assay. Check activated clotting time ACT 5-10 minutes after bolus dose is completed.
Aminoglycosides distribute very poorly into adipose tissue. If you hold down the shift key you can select an entire range of drugs for example you can click on the first drug in the list and then while holding the shift key select the last drug and you will notice that the. Required data entry fields are teal in color.
Please seek haematology advice if necessary. However these differences were not statistically different. Therapeutic Goal Range for PTT is 55-100.
This program allows for multiple selections. The use of weight based anticoagulants such as argatroban may put obese patients at an increased risk of hemorrhagic events. Use ideal body weight IBW except if obese.
When initiated argatroban should be dosed the same in those with HITT and isolated HIT. Argatroban is a a small molecule synthetic direct thrombin inhibitor. Aminoglycosides distribute very poorly into adipose tissue.
Adult tobramycin traditional dosing calculator is based on a calculation method proposed by Sarubbi and Hull. Argatroban should be continued as bridging therapy with oral anticoagulation of the coumarin type for a. Amiodarone 450 mg per 250 ml Amiodarone 900 mg per 500 ml Bivalirudin 250 mg per 50 ml Bivalirudin 500 mg per 100 ml Diltiazem 125 mg per 125 ml Dobutamine 500 mg per 250 ml.
To calculate INR for warfarin alone INR W based on INR for co-therapy of warfarin and Argatroban INR WA when the Argatroban dose is 2 mcgkgmin use the equation next to the appropriate curve. In the open-label extension over an average duration of 73 weeks of treatment the overall rate of. The purpose of this study was to evaluate argatroban dosing requirements in obese vs non-obese patients.
Start 05 mcgkgmin titrate slowly anticoagulation PCI adjunct hepatic impairment. Marchetti and colleagues critically and systematically reviewed their institutional experience using this direct thrombin inhibitor to treat patients with laboratory-confirmed HIT and have formulated several practical recommendations for managing this. Obesity is associated with significant alterations in pharmacokinetic and pharmacodynamic properties.
Other fields are output only. Depending on units selected the general composition for the formula is as follows. IV Drip Rate mLhour 60minhr Desired Dose in mcgkgmin Weight in kg Bag Volume in mL 1000 mcgmg Drug in Bag in mg.
Dosing and monitoring of argatroban for treatment of heparin-induced thrombocytopenia HIT remain uncertain. O Initiate dose at 05 mcgkgmin o Half-life can be extended up to 180 minutes 3 x normal half-life of 39-51 minutes In patients with renal impairment o Argatroban is not renally eliminated and does not require initial dosage adjustments Clinical conditions which may warrant dosing as low as 01 or 02 mcgkgmin. You will find a medical calculator for BMI clinical calculator for creatinine clearance metric to english conversion and more.
Calculations and document all dose changes on the Argatroban Flow Sheet. In the 12-week controlled phase the rate of all infections in the ACTEMRA-IV group was 345 per 100 patient-years and 287 per 100 patient-years in the placebo group. Select Drug and Concentration.
And even over 20 financial calculators related to retirement savings investments mortgages and loans. Get the app to quickly determine an ideal vancomycin regimen estimate a steady-state trough concentration and adjust an existing regimen. Maximum dose 10mcgkgmin Switching to warfarin.
The dose for heparin-induced thrombocytopenia without hepatic impairment is 2 mcgkgmin administered as a continuous infusion 21 Discontinue heparin therapy and obtain a baseline aPTT before administering Argatroban 21 After the initial dose of Argatroban the dose can be adjusted as clinically indicated 21. To pick and choose one drug at a time hold down the ctrl key and make as many selections as you need. Therefore obese patients actual body weight 120 of IBW require a correction in the weight used for V d calculation and dose.
Therefore obese patients actual body weight 120 of IBW require a correction in the weight used for V d calculation and dose. Get the Vancomycin Dosing Calculator - A HughesMedicine App. PTT Rate Adjustment Recheck PTT from time of dose change Normal Hepatic Function.
Dosing and titrating argatroban. Child-Pugh Class B or C. It is used as an alternative anticoagulant in patients with heparin-induced thrombocytopenia HIT.
Adult amikacin traditional dosing calculator is based on a calculation method proposed by Sarubbi and Hull. Stopping this drug too early could result in a lapse in therapeutic anticoagulation. Start dose amount not defined titrate slowly.
Doses between 015 to 13 mcgkgminute were required to maintain aPTTs in the target range Reichert 2003. Indicated as an anticoagulant in patients with or at risk for heparin-induced thrombocytopenia undergoing percutaneous coronary intervention PCI Initial. Co-administered with Argatroban at a dose of 2 mcgkgmin.
Argatroban Versus Heparin In Patients Without Heparin Induced Thrombocytopenia During Venovenous Extracorporeal Membrane Oxygenation A Propensity Score Matched Study Springerlink
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Pdf Weight Based Argatroban Dosing Nomogram For Treatment Of Heparin Induced Thrombocytopenia
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